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#DNA TO RNA SEQUENCE SERIES#
In a series of experiments, the researchers tested polymerase theta against the reverse transcriptase from HIV. Like polymerase theta, HIV reverse transcriptase acts as a DNA polymerase, but can also bind RNA and read RNA back into a DNA strand.
The researchers therefore noticed that some of polymerase theta’s “bad” qualities were ones it shared with another cellular machine – reverse transcriptase. This repairs DNA, but is error-prone and produces mutations.
The team started by investigating polymerase theta. For example, this finding suggests that RNA messages can be used as templates for repairing or re-writing genomic DNA.
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